< em > Cistus incanus < /em > : a natural source of antimicrobial metabolites

In this study, we analysed the spectrum of molecules composing a commercial hydroalcoholic extract of C. incanus finding ellagitannins as the most abundant. The effect of the extract and its main constituents (gallic acid, ellagic acid and punicalin) was assessed as co-treatment during viral (HSV-1, HCoV-229E, SARS-CoV-2) and bacterial infection (Staphylococcus aureus and Escherichia coli) of cells and as pre-treatment before virus infections. The results indicated a remarkable antiviral activity of punicalin against SARS-CoV-2 by pre-treating both the viral and the host cells, and a major sensitivity of S. aureus to the C. incanus extract compared to E. coli. The present study highlights broad antimicrobial potential of C. incanus extract.PMID:38557224 | DOI:10.1080/14786419.2024.2335353

Source: Natural Product Research - April 1, 2024 Category: Biochemistry Authors: Anna De Filippis Vincenzo D'Amelia Veronica Folliero Carla Zannella Gianluigi Franci Massimiliano Galdiero Antonio Di Loria Carmen Laezza Simona Maria Monti Anna Lisa Piccinelli Rita Celano Maria Manuela Rigano Source Type: research