miR-200c-141 induces a hybrid E/M state and promotes collective cell migration in MDA-MB-231 cells

In this study, we investigated whether the miR-200 family members play a role in the acquisition of a hybrid epithelial/mesenchymal (E/M) state, which is reported to be associated with cancer malignancy, in mesenchymal MDA-MB-231 cells. Our results demonstrated that the induction of miR-200c-141, a cluster of the miR-200 family member, can induce the expression of epithelial gene and cell-cell junction while mesenchymal markers are retained. Moreover, induction of miR-200c-141 promoted collective migration accompanied by the formation of F-actin cables anchored by adherens junction. These results suggest that the miR-200 family can induce a hybrid E/M state and endows with the ability of collective cell migration in mesenchymal cancer cells.PMID:38552553 | DOI:10.1016/j.bbrc.2024.149829
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research