Cancers, Vol. 16, Pages 1368: FXR Agonism with Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden

In conclusion, agonism of FXR by primary bile acid memetic OCA yields potent anti-tumor effects potentially through inhibition of proliferation and migration and reduced cell viability. These findings suggest that FXR is a tumor suppressor gene with a high potential for use in personalized therapeutic strategies for individuals with BC.

Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Sydney C. Joseph Samson Eugin Simon Margaret S. Bohm Minjeong Kim Madeline E. Pye Boston W. Simmons Dillon G. Graves Stacey M. Thomas-Gooch Ubaid A. Tanveer Jeremiah R. Holt Suriyan Ponnusamy Laura M. Sipe D. Neil Hayes Katherine L. Cook Ramesh Narayanan Tags: Article Source Type: research