Dynamic changes and clinical value of lipocalin 2 in liver diseases caused by microbial infections

World J Hepatol. 2024 Feb 27;16(2):177-185. doi: 10.4254/wjh.v16.i2.177.ABSTRACTLipocalin 2 (LCN2) plays a pivotal role in iron metabolism, particularly in the context of microbial infection resistance (e.g., viruses, bacteria, parasites, etc.). LCN2 combats microbial infection by directly assisting the body in competing with microorganisms for iron, inducing immune cells to secrete various cytokines to enhance systemic immune responses, or recruiting neutrophils to infectious sites. The liver serves as the primary organ for LCN2 secretion during microbial infections. This review encapsulates recent advances in dynamic changes, clinical values, and the effects of LCN2 in infectious liver diseases caused by various microbial microorganisms.PMID:38495277 | PMC:PMC10941746 | DOI:10.4254/wjh.v16.i2.177

Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Feng Chen Shan-Shan Wu Chao Chen Cheng Zhou Source Type: research