Cancers, Vol. 16, Pages 1347: Targeted DNA Sequencing of Cutaneous Melanoma Identifies Prognostic and Predictive Alterations

Conclusions: NRAS mutation in CMs correlated with significantly worse overall survival. Elevated TMB was associated with increased progression-free survival for patients treated with a combination of dual ICI, supporting the potential utility of TMB as a predictive biomarker for ICI response in melanoma.

Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Alexandra M. Haugh Robert C. Osorio Rony A. Francois Michael E. Tawil Katy K. Tsai Michael Tetzlaff Adil Daud Harish N. Vasudevan Tags: Article Source Type: research