Liraglutide attenuates angiotensin II-induced aortic dissection and aortic aneurysm via inhibiting M1 macrophage polarization in APOE < sup > -/- < /sup > mice

CONCLUSION: Our study found liraglutide exhibits protective effects against AAD by modulating M1 macrophage polarization, suppressing CXCL3 expression through the PI3K/AKT signaling pathway. This makes it a promising therapeutic target for AAD, offering a new avenue in AAD management.PMID:38548245 | DOI:10.1016/j.bcp.2024.116170
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research