Fully human anti-CD19 CAR T cells derived from systemic lupus erythematosus patients exhibit cytotoxicity with reduced inflammatory cytokine production

CONCLUSION: Hu19-CD828Z CAR T cells generated from SLE patient lymphocytes demonstrate CAR-mediated and CD19-dependent activity against autologous primary B cells with reduced inflammatory cytokine production supporting KYV-101 as a novel potential therapy for the depletion of pathogenic B cells in SLE patients.PMID:38548226 | DOI:10.1016/j.jtct.2024.03.023

Source: Cancer Control - March 28, 2024 Category: Cancer & Oncology Authors: Janin Dingfelder Michael Aigner Jule Taubmann Ioanna Minopoulou Soo Park Charles D Kaplan Joseph K Cheng Tom Van Blarcom Georg Schett Andreas Mackensen Gloria Lutzny-Geier Source Type: research