Neuropsychiatric profiles and cerebral amyloid burden in adults without dementia

CONCLUSIONS: In a cohort of older adults without dementia, both self- and informant-reported measures of global NPS, particularly patient-reported cognitive concerns and informant-reported anxiety and depression, corresponded with cerebral Aβ burden. NPS may appear early in the prodromal disease state and relate to initial AD proteinopathy burden, a relationship further exaggerated in those with greater clinical severity.PMID:38513620 | DOI:10.1159/000538376

https://pubmed.ncbi.nlm.nih.gov/38513620/?utm_source=no_user_agent&utm_medium=rs...

Source: Dementia and Geriatric Cognitive Disorders - March 21, 2024 Category: Psychiatry Authors: Eva Q Gontrum Emily W Paolillo Shannon Lee Valentina Diaz Alexander Ehrenberg Rowan Saloner Nidhi S Mundada Renaud La Joie Gil Rabinovici Joel H Kramer Kaitlin Casaletto Source Type: research