Personalized Protein-Protein Interaction Networks Towards Unraveling the Molecular Mechanisms of Alzheimer ’s Disease

In this study, we adopted a personalized approach and analyzed the transcriptome data from 403 patients individually by mapping the data on a human protein-protein interaction network. Patient-specific subnetw orks were discovered and analyzed in terms of the genes in the subnetworks, enriched functional terms, and known AD genes. We identified several affected pathways that could not be captured by the bulk comparison. We also showed that our personalized findings point to patterns of alterations consist ent with the recently suggested AD subtypes.
Source: Molecular Neurobiology - Category: Neurology Source Type: research