Cognitive decline, A β pathology, and blood–brain barrier function in aged 5xFAD mice

Conclusion5xFAD mice continue to develop spatial memory deficits and increased A β brain levels while aging. Given in vivo MP imaging limitations, further investigation with smaller molecular weight markers combined with advanced imaging techniques would be needed to reliably assess subtle differences in barrier integrity in aged mice.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research