Cooperative interaction of interferon regulatory factor -1 and bromodomain —containing protein 4 on RNA polymerase activation for intrinsic innate immunity

ConclusionsWe conclude that the IRF1 functions in two modes- in absence of infection, ambient IRF1 mediates constitutive expression of the intrinsic IIR, whereas in response to RSV infection, the BRD4 CRC independently activates pSer2 Pol II to mediates robust expression of the intrinsic IIR. These data provide insight into molecular control of anti-viral defenses of airway basal cells.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research