Where alcohol use disorder meets interoception: A meta ‐analytic view on structural and functional neuroimaging data

We examined the results of two meta-analyses of gray matter reduction in alcohol use disorders (AUD) and functional representations of interoception (INT) for spatial convergence. No overlap was found (A). However, the AUD clusters are located in regions of the salience and sensorimotor networks that are strongly associated with the interoception clusters, as determined by coactivation (MACM; B, C) and resting-state analyses (D). Weak salience mapping may account for Interoceptive deficits in AUD that may be influenced by sensory stimulation. AbstractAlcohol use disorder (AUD) has been associated with changes in the processing of internal body signals, known as interoception. Changes in brain structure, particularly in the insula, are thought to underlie impaired interoception. As studies specifically investigating this association are largely lacking, this analysis takes an approach that compares meta-analytic results on interoception with recently published meta-analytic results on gray matter reduction in AUD. A systematic literature search identified 25 eligible interoception studies. Activation likelihood estimation (ALE) was used to test for spatial convergence of study results. Overlap between interoception and AUD clusters was tested using conjunction analysis. Meta-analytic connectivity modeling (MACM) and resting-state functional connectivity were used to identify the functional network of interoception and to test where this network overlapped with AUD meta-analyti...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research