Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy

In this study, we reveal the pivotal role of RNA-binding motif protein 46 (RBM46) in ESCs, acting as a direct post transcriptional regulator of ROS levels by modulating BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) mRNA expression. Rbm46 knockout lead to diminished mitochondrial autophagy, culminating in elevated ROS within ESCs, disrupting the delicate balance required for healthy self-renewal. These findings provide insights into a novel mechanism governing ROS regulation in ESCs.PMID:38518724 | DOI:10.1016/j.bbrc.2024.149779

Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Jinchen Zhong Jing Xu Xiaoyang Chen Na Li Sha Li Zhiwen Deng Huimin Feng Xiaohan Ling Chenchen Wang Zhi Zhou Lingsong Li Source Type: research