Untargeted NMR-based metabolomics analysis of kidney allograft perfusates identifies a signature of delayed graft function

ConclusionsThe metabolome of kidney grafts is influenced by the donor ’s type in both human and pre-clinical studies and could be correlated with DGF in the human DBD cohort. Thus, metabolomic analysis of perfusate applied prior to KTx may represent a new predictive tool for clinicians in a more personalized management of DGF. Moreover, our data paves the way to bet ter understand the impact of donor’s types on the biochemical events occurring between death and the hypothermic storage.
Source: Metabolomics - Category: Biology Source Type: research