Pulmonary vasodilators and exercise in Fontan circulation: a systematic review and meta-analysis

Conclusions Although PAH-targeted therapies did not affect exercise parameters at maximal effort, they induced slight improvements in indices of submaximal effort, measured at the anaerobic threshold. Pharmacological improvement of submaximal exercise seems to be a more suitable indicator of Fontan individuals’ exercise capacity. Larger RCTs, recruiting specific subpopulations and focusing also on the anaerobic threshold, are warranted to draw more robust conclusions. PROSPERO registration number CRD42022306674.

http://heart.bmj.com/cgi/content/short/110/8/552?rss=1

Source: Heart - March 22, 2024 Category: Cardiology Authors: Kosmidis, D., Arvanitaki, A., Farmakis, I. T., Liakos, A., Giannopoulos, A., Ziakas, A., Giannakoulas, G. Tags: Systematic review Source Type: research