NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats

CONCLUSION: This study showed the activation of the NGF/TrKA signaling pathway in KOA promoted the release of pain mediators, increased the innervation of sensory nerve fibers in the synovium, and worsened peripheral hyperalgesia. It also showed increased TRPV1 positive sensory innervation in KOA was mediated by NGF/TrKA signaling and exacerbated peripheral hyperalgesia.PMID:38410126 | PMC:PMC10896652 | DOI:10.1155/2024/1552594

Source: Pain Research and Management - February 27, 2024 Category: Anesthesiology Authors: Zixiu Liu Mingchao Li Li Zhang Xiaoqing Shi Taiyang Liao Lishi Jie Likai Yu Peimin Wang Source Type: research