Oxygen Vacancy ‐Rich Manganese Nanoflowers as Ferroptosis Inducers for Tumor Radiotherapy

Theovs-MnO2 enhances radiotherapy by inducing ferroptosis and modifying the tumor microenvironment. It catalyzes H2O2, releasing O2 and hydroxyl radicals while depleting glutathione. Simultaneously, enriched oxygen vacancies inovs-MnO2 prompt the release of intracellular Fe2+, activating lipid peroxidation and ferroptosis. This dual action, inactivating GPX4 and inducing ferroptosis in tumor cells, boosts the therapeutic efficiency of radiotherapy. AbstractThe combination of ferroptosis and innovative tumor therapy methods offers another promising answer to the problem of tumors. In order to generate effective ferroptosis in tumor cells, iron-based nanomaterials are commonly utilized to introduce foreign iron as a trigger for ferroptosis. However, this usually necessitates the injection of larger doses of iron into the body. These exogenous iron increases are likely to create concealed concerns for symptoms such as liver damage and allergy. Herein, an iron-free radiosensitizer is introduced, oxygen-vacancy-rich MnO2 nanoflowers (ovs-MnO2), that promotes ferroptosis and modifies the tumor microenvironment to assist radiotherapy.ovs-MnO2 with enriched oxygen vacancies on the surface induces the release of intracellular free iron (Fe2+), which functions as an activator of Fenton reaction and enhances the accumulation of intracellular reactive oxygen species. On the other hand, Fe2+ also triggers the ferroptosis and promotes the accumulation of lipid peroxides. Subsequently, the ...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research