Comparative analysis of basal and etoposide-induced alterations in gene expression by DNA-PKcs kinase activity

Conclusion: Overall, our results indicate that DNA-PKcs, in a kinase-dependent fashion, decreases proinflammatory signaling following genotoxic insult. As multiple DNA-PK kinase inhibitors are in clinical trials as cancer therapeutics utilized in combination with DNA damaging agents, understanding the transcriptional response when DNA-PKcs cannot phosphorylate downstream targets will inform the overall patient response to combined treatment.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research