Exacerbated ischemia-reperfusion injury in fatty livers is mediated by lipid peroxidation stress and ferroptosis

Ischemia-reperfusion injury is a common problem in liver surgery and transplantation. Although ischemia-reperfusion injury is known to be more pronounced in fatty livers, the underlying mechanisms for this difference remain poorly understood. We hypothesized that ferroptosis plays a significant role in fatty liver ischemia-reperfusion injury due to increased lipid peroxidation in the presence of stored iron in the fatty liver. To test this hypothesis, the ferroptosis pathway was evaluated in a murine fatty liver ischemia-reperfusion injury model.

Source: Surgery - March 20, 2024 Category: Surgery Authors: Zachary P. Rokop, Wenjun Zhang, Nandini Ghosh, Nirupam Biswas, Amitava Das, Jingmei Lin, Chandan K. Sen, Chandrashekhar Kubal Source Type: research