New penta-coordinated cadmium(II) complexes: Synthesis, Characterization, Thermal, Antimicrobial, Antioxidant and Cytotoxicity Properties

Chem Biodivers. 2024 Mar 19:e202301667. doi: 10.1002/cbdv.202301667. Online ahead of print.ABSTRACTIn this paper, a new tridentate Schiff base ligand (L) with nitrogen donor atoms and its cadmium(II) complexes with the general formula of CdLX2 (X= Cl-,Br-,I-,SCN-,N3-,NO3-) have been synthesized and characterized by physical and spectral methods. Also nano-structured cadmium chloride and bromide complexes were synthesized by sonochemical method and then used to prepare nanostructured cadmium oxide confirmed by XRD and SEM techniques. Thermal behavior of the compounds was studied in the temperature range of 25 to 900 °C under N2 atmosphere at a heating rate of 20 °C/ min. Moreover, thermo-kinetic activation parameters of thermal decomposition steps were calculated according to the Coats-Redfern relationship. Antimicrobial activities of the synthesized compounds against two gram-positive and two gram-negative bacteria and two fungi were investigated by well diffusion method. SEM technique was used to monitor the morphological changes of the bacteria treated with the compounds. The DPPH and the ferric reducing antioxidant power (FRAP) methods were used to evaluate the antioxidant ability of the ligand and its cadmium(II) complexes. In final, the cytotoxicity properties of the ligand and some cadmium(II) complexes against PC3 cancer cells were evaluated by MTT bioassay and nitric oxide (NO) level measurement.PMID:38502834 | DOI:10.1002/cbdv.202301667
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research