Validation and shortcomings of the most common mouse model of chronic rhinosinusitis with nasal polyps

CONCLUSIONS: With the notable exception of local IgE production, the addition of SEB did not induce additional inflammatory or structural change in the sinuses from mice exposed to and challenged with OVA. This model might represent a model for severe upper airway allergy rather than a specific model of human eCRSwNP.PMID:38497676 | DOI:10.4193/Rhin23.331

Source: Rhinology - March 18, 2024 Category: ENT & OMF Authors: A S ánchez-Montalvo M Lecocq E Bouillet B Steelant S Gohy A Froidure D Bullens C Pilette V Hox Source Type: research