SOX ‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report

We report a patient with LEMS who was tested positive for SOX-1 antibodies and was definitively diagnosed with SCLC by pathological biopsy after 10  months follow-up. AbstractLambert –Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic neurological syndrome of the neuromuscular transmission. The symptoms often progress slowly and can be misdiagnosed in early stage. Seropositive SOX-1 antibodies are support for the diagnosis of LEMS and have high specificity for small cel l lung cancer (SCLC). In this paper, we report a case of a 56-year-old man with smoking history who was admitted to hospital with progressive muscle weakness of the proximal legs. LEMS was diagnosed by repetitive nerve stimulation (RNS) testing and seropositive SOX-1 antibodies. Primary screening wi th chest computed tomography (CT) and integrated PET/CT did not reveal any tumor. After continuous follow-up, SCLC was found by chest CT and confirmed with pathological examination 10 months after the diagnosis of LEMS. Long-term follow-up and screening for occult SCLC in LEMS patients with positiv e SOX-1 antibodies are very important.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: BRIEF REPORT Source Type: research