Cancers, Vol. 16, Pages 1200: Accuracy of Frozen Section Biopsy in the Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis

Cancers, Vol. 16, Pages 1200: Accuracy of Frozen Section Biopsy in the Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers16061200 Authors: Stergios Kopatsaris Aikaterini Apostolopoulou Ioannis Tsakiridis Antigoni Tranidou Fotios Zachomitros Evangelos Papanikolaou Alexandros Daponte Ioannis Kalogiannidis Themistoklis Dagklis The early and accurate diagnosis of endometrial cancer is of paramount importance for the survival of these patients. The aim of this study was to systematically appraise the available data regarding the accuracy of frozen section biopsy in diagnosing endometrial cancer. A thorough literature search was performed in PubMed/Medline, Scopus and the Cochrane Central Register of Controlled Trials databases from inception up to January 2023, with the use of specific, relevant key terms. A quality evaluation for each study was performed with the QUADAS-2 tool, whereas a bivariate random-effect model was performed to generate a summary receiver-operated curve. Heterogeneity was evaluated with Cochrane Q and Higgins’ I2 statistics. Subgroup analyses were performed for studies focused on atypical hyperplasia and those focused on endometrial cancer. The search yielded 47 studies, involving 7790 patients with endometrial cancer. Among them, only 11 could be included in the quantitative analysis. QUADAS-2 evaluation resulted in rather high quality among the included studies. Quantit...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Systematic Review Source Type: research