Sleep deprivation changes frequency-specific functional organization of the resting human brain

In this study, thirty-seven healthy male subjects underwent resting-state fMRI during rested wakefulness (RW) and after 36hours of SD, and we examined frequency-specific spectral connection changes (0.01-0.08Hz, interval = 0.01Hz) caused by SD. First, we conducted a multivariate pattern analysis combining linear SVM classifiers with a robust feature selection algorithm, and the results revealed that accuracies of 74.29%-84.29% could be achieved in the classification between RW and SD states in leave-one-out cross-validation at different frequency bands, moreover, the spectral connection at the lowest and highest frequency bands exhibited higher discriminative power. Connection involving the cingulo-opercular network increased most, while connection involving the default-mode network decreased most following SD. Then we performed a graph-theoretic analysis and observed reduced low-frequency modularity and high-frequency global efficiency in the SD state. Moreover, hub regions, which were primarily situated in the cerebellum and the cingulo-opercular network after SD, exhibited high discriminative power in the aforementioned classification consistently. The findings may indicate the frequency-dependent effects of SD on the functional network topology and its efficiency of information exchange, providing new insights into the impact of SD on the human brain.PMID:38493835 | DOI:10.1016/j.brainresbull.2024.110925
Source: Brain Research Bulletin - Category: Neurology Authors: Source Type: research