Decreased interleukin ‐17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice

ConclusionReduced IL-17RA expression also suppressed cellular proliferation, migration, and invasion, and the expression of EMT genes. Knockdown of IL-17RA inhibited tumor growth and vascularity and decreased the population of Tregs and MDSCs in mouse tumors. Overall, IL-17RA expression was identified to be independently associated with the prognosis of patients with CRC.

Source: Cancer Medicine - March 17, 2024 Category: Cancer & Oncology Authors: Jeng ‐Kai Jiang, Chi‐Hung Lin, Ting‐An Chang, Liang‐Chuan Lo, Chien‐Ping Lin, Ruey‐Hwa Lu, Chih‐Yung Yang Tags: RESEARCH ARTICLE Source Type: research