Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study

Adaptor proteins stress induced phosphoprotein 1 (STIP1) and ST13 Hsp70 interacting protein (ST13) may play a crucial role in the pathophysiology of ischemic stroke through controlling protein folding, neuronal survival, and regulation of HSP70/HSP90. The present pilot study investigated whether tagSNPs in genes encoding ST13 (rs138335,rs138344,rs7290793, andrs138344) and STIP1 (rs4980524) are associated with ischemic stroke. DNA samples from 721 ischemic stroke patients and 471 healthy controls were genotyped using the MassArray-4. Our research revealed a relationship betweenrs138344 ST13 and the risk of ischemic stroke, which was seen only in females (risk alleleG; OR=1.34, 95%CI=1.07-1.69;p=0.01). The haplotypers138335G-rs138344C-rs7290793C ST13 was linked with lower risk of ischemic stroke in females: OR=0.42; 95%CI=0.26-0.68;p=0.0005. Thus,ST13 represents a novel genetic marker for ischemic stroke.
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research