Whole-Body Positron Emission Tomography with 18F-Fluorodeoxyglucose/Magnetic Resonance Imaging as a Screening Tool for the Detection of Malignant Transformation in Individuals with Neurofibromatosis Type 1
Malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of death in patients with neurofibromatosis type 1. They can result from premalignant neurofibromas, including neurofibromas with atypia and atypical neurofibromatous neoplasms of uncertain biologic potential. Some phenotypic characteristics have been described as associated with their development. The aim of this study was to outline our use of whole-body positron emission tomography with 18F-fluorodeoxyglucose/magnetic resonance imaging in adults with neurofibromatosis type 1, especially in the screening of asymptomatic individuals with a higher risk of developing an MPNST, and to study its impact on neurofibroma classification (malignant vs premalignant) and MPNST staging over time.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Laura Fertitta, Arnaud Jannic, Ouidad Zehou, Christina Bergqvist, Salah Ferkal, Sabine Moryousef, Lionel Lerman, S ébastien Mulé, Alain Luciani, Blanche Bapst, Khaled Ezzedine, Nicolas Ortonne, Emmanuel Itti, Pierre Wolkenstein Tags: Original Article Source Type: research
More News: Brain | Cancer & Oncology | Dermatology | MRI Scan | Neurofibromatosis | Neurology | PET Scan | Skin | Study