Pathophysiology of chikungunya virus infection associated with fatal outcomes
Cell Host Microbe. 2024 Mar 8:S1931-3128(24)00054-4. doi: 10.1016/j.chom.2024.02.011. Online ahead of print.ABSTRACTChikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomic, proteomic, and genomic analyses to investigate viral and host factors that contribute to chikungunya-associated (CHIK) death. Our results indicate that CHIK deaths are associated with multi-organ infection, central nervous system damage, and elevated serum levels of pro-inflammatory cytokines and chemokines compared with survivors. The histopathologic, metabolite, and proteomic signatures of CHIK deaths reveal hemodynamic disorders and dysregulated immune responses. The CHIKV East-Central-South-African lineage infecting our study population causes both fatal and survival cases. Additionally, CHIKV infection impairs the integrity of the blood-brain barrier, as evidenced by an increase in permeability and altered tight junction protein expression. Overall, our findings improve the understanding of CHIK pathophysiology and the causes of fatal infections.PMID:38479396 | DOI:10.1016/j.chom.2024.02.011
Source: Cell Host and Microbe - Category: Microbiology Authors: William M de Souza Marcilio J Fumagalli Shirlene T S de Lima Pierina L Parise Deyse C M Carvalho Cristian Hernandez Ronaldo de Jesus Jeany Delafiori Darlan S Candido Victor C Carregari Stefanie P Muraro Gabriela F Souza Leda M Sim ões Mello Ingra M Claro Source Type: research
More News: African Health | Brain | Chikungunya | Epidemiology | Microbiology | Neurology | South Africa Health | Study | Virology