Smallest Clinically Meaningful Improvement in Amputation-Related Pain and Brief Pain Inventory Scores as Defined by Patient Reports of Global Improvement After Cryoneurolysis: a Retrospective Analysis of a Randomized, Controlled Clinical Trial

CONCLUSIONS: Amputees with phantom limb pain treated with percutaneous cryoneurolysis rate analgesic improvements as clinically meaningful similar to pharmacologic treatments, although their MCID for the Brief Pain Inventory was somewhat larger than previously published values. This information on patient-defined clinically meaningful improvements will facilitate interpretation of available studies and guide future trial design.PMID:38478876 | DOI:10.1213/ANE.0000000000006833

Source: Anesthesia and Analgesia - March 13, 2024 Category: Anesthesiology Authors: Brian M Ilfeld Cameron R Smith Alparslan Turan Edward R Mariano Matthew E Miller Rick L Fisher Andrea M Trescot Steven P Cohen James C Eisenach Daniel I Sessler J David Prologo Edward J Mascha Liu Liu Rodney A Gabriel PAINfRE Investigators Source Type: research