Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study

DISCUSSION: Gait slowness in APOE E4 carriers with neurodegenerative diseases may indicate extensive gray matter changes associated with poor cognition.HIGHLIGHTS: APOE E4 and slow gait are risk factors for cognitive decline in neurodegenerative diseases. Slow gait and smaller gray matter volumes are associated, independently of APOE E4. Worse cognition in APOE E4 carriers with slow gait is explained by smaller GM volume. Gait slowness in APOE E4 carriers indicates poorer cognition-related brain changes.PMID:38470007 | DOI:10.1002/alz.13740

Source: The Journal of Alzheimers Association - March 12, 2024 Category: Psychiatry Authors: Ryota Sakurai Frederico Pieruccini-Faria Benjamin Cornish Julia Fraser Malcolm A Binns Derek Beaton Allison Ann Dilliott Donna Kwan Joel Ramirez Brian Tan Christopher J M Scott Kelly M Sunderland Carmela Tartaglia Elizabeth Finger Lorne Zinman Morris Free Source Type: research