Combining directed evolution with high cell permeability for high-level cadaverine production in engineered Escherichia coli
This study demonstrates the potential role of LPS in enhancing the efficiency of mass transfer between substrate and enzymes in vivo by increasing cell permeability. The results indicate that the argumentation of cell permeability could not only significantly enhance the biotransformation efficiency of cadaverine, but also provide a universally applicable, straightforward, environment-friendly, and cost-effective method for the biosynthesis of other high-value chemicals.PMID:38472088 | DOI:10.1002/biot.202300642
Source: Biotechnology Journal - Category: Biotechnology Authors: Xuemei Liu Ruoshi Luo Dan Wang Kaixing Xiao Fanzhen Lin Ya Qi Kang Xue Xia Xiaojie Zhou Ge Hu Source Type: research