HPV Serology and Circulating Viral DNA for Detection, Genotyping, and Risk-Stratification in p16+ Oropharyngeal Cancer

The incidence of human papillomavirus-positive (HPV+) oropharyngeal cancer (OPC) has increased rapidly in North America. HPV serology has been proposed as a sensitive, scalable, and cost-effective early detection test. HPV seropositivity can precede clinical presentation of OPC by several years, so additional diagnostic and/or surveillance procedures may be necessary to optimize early cancer detection. The potential for HPV circulating tumor DNA (ctDNA) to confirm a diagnosis of OPC in seropositive individuals is poorly understood.

Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: L. Penny, E. Stutheit-Zhao, Z. Zhao, Y. Zheng, J. Zou, S.H. Huang, J. de Almeida, D. Goldstein, A.J. Hope, A. Hosni, J. Kim, F.F. Liu, C.J. Tsai, J. Waldron, A. Spreafico, E. Sanz Garcia, L.L. Siu, T. Waterboer, G. Liu, S.V. Bratman Tags: 5 Source Type: research