Aspiration Rates and Clinician-graded Dysphagia after Transoral Surgery (TOS): An Interim Analysis of Modified Barium Swallow (MBS) Studies (videofluoroscopy) from the PATHOS trial

PATHOS is an ongoing Phase II/III randomized trial examining risk-stratified de-escalated adjuvant therapy after transoral surgery (TOS) for human papillomavirus associated oropharyngeal cancer. While the goal of TOS is functional preservation, acute postsurgical dysphagia is expected with post-TOS aspiration prevalence (prior to adjuvant treatment) recently reported in 13% of patients from the E3311 trial. Our objective was to assess clinician-graded swallowing function per modified barium swallow (MBS, videofluoroscopy) in the PATHOS trial before and after TOS, prior to randomization for adjuvant therapy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: 171 Source Type: research