Prospective Study of Plasma Biomarker-Guided Surveillance of HPV-positive Oropharynx Cancer Using TTMV-HPV DNA: The SPHERE Study

Previous observational studies suggest that circulating tumor HPV DNA may facilitate early detection of recurrent HPV-positive oropharynx cancer (OPC). This is the first prospective cohort study to investigate whether biomarker-guided surveillance detects recurrent disease sooner than standard of care.

Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: E.M. Rettig, J. Miller, B. Sargent, E. Carey, R.I. Haddad, D.N. Margalit, K. Sehgal, R. Sethi, R. Uppaluri, R.B. Tishler, L. Goguen, D.J. Annino, E. Sim, V. Jo, K. Wong, J.P. Guenette, J.D. Schoenfeld, G.J. Hanna Tags: 177 Source Type: research