Generalized Pairwise Comparisons Method to Assess Total Severe Oral Mucositis Burden and Interventional Benefit in HNC
Severe oral mucositis (SOM, WHO Gr 3-4) is a common and debilitating side effect of intensity-modulated radiation therapy (IMRT) and concurrent cisplatin (CRT) in patients with head and neck cancer (HNC). Patient SOM burden is defined by multiple endpoints (incidence, duration, severity and time to onset) and it is critical to consider all in a “holistic” approach rather than a single endpoint. Generalized pairwise comparisons (GPC) statistical method allows combined assessment, while accounting for testing multiplicity.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: C.M. Anderson, S. Salvaggio, M. De Backer, J.C. Chiem, G.V. Walker, D. Saunders, C.M. Lee, N.E. Dunlap, E. Kennedy, B. Schoen, R. Beardsley, M. Buyse Tags: 226 Source Type: research
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