Early Disease Recurrence Following Post-operative HPV ctDNA Directed Active Surveillance in Oropharyngeal Carcinoma – Outcomes of a Prospective Pilot Study

Human papilloma virus cell-free tumor DNA (HPV ctDNA) may be able to detect minimal residual disease prior to clinically apparent recurrence. We hypothesized that undetectable post-operative HPV ctDNA can be used to select patients for active surveillance and conducted a pilot study (NCT05307939) omitting or delaying adjuvant radiation until patients develop detectable HPV ctDNA (cohort A).

Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: L. Chen, M. Cohen, V. Hatzoglou, Z. Zhang, N. Riaz, R.J. Wong, S. McBride, D. Gelblum, J.O. Boyle, I. Ganly, L.G. Morris, B. Singh, J. Cracchiolo, Y. Yu, K. Zakeri, A. Shamseddine, L. Dunn, D.G. Pfister, E. Sherman, N.Y. Lee Tags: LBA 01 Source Type: research