Probes for the heterogeneity of muscimol binding sites in rat brain

Discussion: These findings indicate that 3H-muscimol binding sites in rat brain are heterogeneous, with different populations of receptors, which are CPZ, LOX or CLZ sensitive or insensitive. These binding sites show a varying distribution in different rat brain regions. Molecular docking suggests that the so-called loop F region of α subunits drives the observed differences.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research