Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage
Conclusions
Seroreactivity against latent and lytic EBV antigens, and in a subset ANO2, was detectable on average a decade before the appearance of a gradually increasing axonal injury occurring in the last decade before the onset of clinical MS. These findings strengthen the hypothesis of latent EBV involvement in the pathogenesis of MS.
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Jons, D., Grut, V., Bergström, T., Zetterberg, H., Biström, M., Gunnarsson, M., Vrethem, M., Brenner, N., Butt, J., Blennow, K., Nilsson, S., Kockum, I., Olsson, T., Waterboer, T., Sundström, P., Andersen, O. Tags: Open access Multiple sclerosis Source Type: research
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