Preclinical Models in Vascularized Composite Allotransplantation

Abstract Vascularized composite allotransplantation (VCA) has the potential to reconstruct any non-visceral tissue defect, using like for like tissue, delivering optimal form and function. Over 150 VCA transplants have been performed worldwide; however, this treatment remains experimental. Things systematically tried in the clinic should follow thorough science and tested in a model that allows predicting as possible the safety of the procedure. This is generally the function of animal experimentation. Advantages of preclinical models include greater control of bias, of subject numbers and of variables compared to clinical trials. Limitations include differences between species in anatomy and physiology as well as ethical, logistical and technical constraints. Multiple models have been described; however, no single model is ideal in all areas. This paper reviews historical perspectives, current models and future direction in VCA research.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Publication date: Available online 22 August 2019Source: Actas Urológicas Españolas (English Edition)Author(s): L.E. Garcia, J. Gonzalez, G. Serena, M. Ammar Al-Nuss, M. Morsi, W. DeFaria, G. Ciancio
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Concentrate growth factor (CGF) is a third-generation platelet concentrate that releases a variety of bioactive substances and plays a good role in promoting tissue healing. Bone marrow mesenchymal stem cell (BMSCs) transplantation has been used to treat osteoporosis. However, effect of bone marrow mesenchymal stem cell combined with concentrate growth factor (CGF) on postmenopausal bone defects remains elusive.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
Transplantation of adipose-derived mesenchymal stem cells (ADSCs) has become a promising approach for bone regeneration therapies, particularly in elderly patients. However, poor cell survival in vivo after implantation due to the ischemic tissue environment has been one of the major limitations of the effectiveness of this strategy. Hypoxia Inducible Factor-1 α (HIF-1α) plays an important role in angiogenic-osteogenic coupling during bone regeneration, as it is a critical mediator of the adaptive cell response to hypoxia.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
Previous reports have shown that treadmill training after spinal cord injury (SCI) contributes to functional recovery and is associated with increased levels of neurotrophic factors in the spinal cord in a rat model. However, the precise mechanism underlying the above observation has not been elucidated. Brain-derived neurotrophic factor (BDNF) is associated with motor function recovery due to its neuroprotective and axon sprouting effects. Promoting BDNF expression in spinal cord lesions by strategies such as physical training and cell transplantation has been reported to be effective in treating SCI in animals.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
Scientists are devising human-animal hybrids for harvesting human organs, but lab-derived mini-organs are a less ethically fraught solution to meeting the need for transplantation.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Background and Aims: The aim of the study was to aid decisions on prognosis and transplantation; this study describes the outcome of children with intestinal failure managed by the multidisciplinary intestinal rehabilitation program at the Royal Children's Hospital, Melbourne. Methods: Retrospective review of children requiring parenteral nutrition (PN) for>3 months who were assessed for home PN between 1991 and 2011. Results: A total of 51 children were included. Forty-two (82%) had short bowel syndrome (SBS), 5 (10%) had chronic intestinal pseudo-obstruction syndrome, and 4 (8%) had congenital enteropathies. M...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research
We examined the performance of two commonly used scores in predicting mortality and a composite endpoint (CEP) consisting of ventricular assist device, heart transplantation or mortality, in women versus men with HF.MethodsA retrospective study of 1,136 (25% women) consecutive ambulatory adult HF patients with reduced left ventricular ejection fraction
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
CONCLUSIONS: Human B1 cells are the key blood group A-specific B cells that have a moderate correlation with anti-A antibody titer and therefore constitute a potential therapeutic target for successful ABO-incompatible transplantation. PMID: 31432639 [PubMed - in process]
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
Therapeutic effect of transplantation of human bone marrow‑derived mesenchymal stem cells on neuron regeneration in a rat model of middle cerebral artery occlusion. Mol Med Rep. 2019 Jul 30;: Authors: Xie P, Deng M, Sun QG, Ma YG, Zhou Y, Ming JH, Chen Q, Liu SQ, Liu JQ, Cai J, Wu F Abstract Human bone marrow‑derived mesenchymal stromal cells (hBMSCs) have been revealed to be beneficial for the regeneration of tissues and cells in several diseases. The present study aimed to elucidate the mechanisms underlying the effect of hBMSC transplantation on neuron regeneration in a rat model of middle cereb...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
AbstractBackgroundRecently, living-donor kidney transplantation from marginal donors has been increasing. However, a simple prediction model for graft function including preoperative marginal factors is limited. Here, we developed and validated a new prediction model for graft function using preoperative marginal factors in living-donor kidney transplantation.MethodsWe retrospectively investigated 343 patients who underwent living-donor kidney transplantation at Kyushu University Hospital (derivation cohort). Low graft function was defined as an estimated glomerular filtration rate of  
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
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