Reappraisal of serum retinol-binding protein as a surrogate marker for retinol and discovery of a novel retinol estimation formula

Serum retinol (ROH) is commonly used for population level assessment of vitamin A status. High-performance liquid chromatography (HPLC) is considered most accurate method for measuring ROH. However, with the technical difficulty of using HPLC for routine assays, serum retinol-binding protein (RBP) measured by immunological assays is expected to be a surrogate marker for ROH, with reports of a close correlation between serum RBP and ROH. Nevertheless, RBP is not commonly tested to assess vitamin A status with concerns over RBP alterations under various physiopathological conditions.

Source: Clinical Nutrition ESPEN - March 12, 2024 Category: Nutrition Authors: Yuri Matsuki, Kiyoshi Ichihara, Yoshihisa Itoh, Kazuo Mori, Hiroshi Ihara, Masato Maekawa, Motoi Nishimura, Sachiko Kiuchi, Fumio Nomura, Naotaka Hashizume, Nobue Itoh, Satoshi Matsumura, of Japan Society of Clinical Chemistry, Nutrition Committee Tags: Original article Source Type: research