Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design

Chronic pancreatitis (CP) is defined by clinical evidence of chronic fibroinflammatory pancreatic injury usually preceded by acute pancreatitis (AP) or recurrent AP. Clinical manifestations include AP, diabetes, exocrine insufficiency, metabolic bone disease, and pancreatic cancer.1 Abdominal pain, the most common symptom, significantly affects quality of life.2 Diagnosing CP relies on cross-sectional imaging features, which are not apparent until later stages. Additionally, the variable clinical presentation and course of CP make reliable diagnosis challenging.

Source: Gastroenterology - February 27, 2024 Category: Gastroenterology Authors: Dhiraj Yadav, Darwin L. Conwell, Stephen J. Pandol, Hanno Steen, Ziding Feng, Liang Li, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Tags: Commentary Source Type: research