The role of podocytes in lupus nephritis: Insights and implications

Clin Immunol. 2024 Mar 8:110180. doi: 10.1016/j.clim.2024.110180. Online ahead of print.ABSTRACTLupus nephritis (LN) is a severe complication of systemic lupus erythematosus, with high mortality rates despite medical advancements. The complexity of its pathogenesis, including the pivotal role of podocytes - kidney-localized cells - remains a challenge, lacking effective treatments and biomarkers. Recent studies highlight the significant contribution of these cells to LN's development, particularly through their immune-related functions and interaction with other kidney cells. This new understanding opens possibilities for targeted therapies aimed at these cellular mechanisms. This review aims to summarize these recent developments, shedding light on the intricate involvement of podocytes in LN and potential avenues for innovative treatments.PMID:38462157 | DOI:10.1016/j.clim.2024.110180
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research