Molecules, Vol. 29, Pages 1236: The Validation and Determination of Empagliflozin Concentration in the Presence of Grapefruit Juice Using HPLC for Pharmacokinetic Applications

In conclusion, our results showed that the co-administration of grapefruit with empagliflozin should be cautiously monitored and avoided, in which grapefruit elevates the plasma level of empagliflozin. This may be attributed to the inhibition of the uridine enzyme in the grapefruit by hesperidin, naringin, and flavonoid.

Source: Molecules - March 11, 2024 Category: Chemistry Authors: Wael Abu Dayyih Zainab Zakaraya Mohammad Hailat Nafe M. Al-Tawarah Sahem Alkharabsheh Haya Khalid Nadher Zeyad Hailat Samia M. Alarman Anas Khaleel Riad Awad Tags: Article Source Type: research