Average temperature as a marker of lymphoma-associated HLH.

Haemophagocytic Lymphohistiocytosis (HLH) is a rare and poorly recognised systemic, hyperinflammatory clinical syndrome associated with a high mortality in those affected.1 In its primary form, HLH is characterised by the presence of genetic abnormalities and typically affects children. Secondary HLH is an altogether more heterogenous condition associated with autoimmune disease, infection and malignancy.2 The pathophysiology of secondary HLH represents immune dysfunction and dysregulation resulting in a continuous cycle of hyperinflammation causing widespread tissue injury.

Source: Clinical Lymphoma, Myeloma and Leukemia - March 10, 2024 Category: Hematology Authors: Cameron Clark, Jack Goddard, Rachel Tattersall, Nick Morley Tags: Original Study Source Type: research