Prevalence of chromosome 8p11.2 translocations and correlation with myeloid and lymphoid neoplasms associated with FGFR1 abnormalities in a consecutive cohort from nine institutions in Japan

Int J Hematol. 2024 Mar 8. doi: 10.1007/s12185-024-03740-0. Online ahead of print.ABSTRACTMyeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or insertions of 8p11.2 were detected. Among the 10 patients with 8p11.2 translocations, three patients were diagnosed with MLN-FGFR1 abnormalities, which were confirmed by FISH analysis. Peripheral blood eosinophilia was observed in all three patients, and all progressed to AML or T-lymphoblastic lymphoma/leukemia. The prevalence of 8p11.2 translocations in clinical practice and the proportion of MLN-FGFR1 abnormalities in patients with 8p11.2 translocations in Japan were consistent with those in previous reports from Western countries.PMID:38457113 | DOI:10.1007/s12185-024-03740-0

Source: International Journal of Hematology - March 8, 2024 Category: Hematology Authors: Kensuke Usuki Takuro Kameda Noriaki Kawano Tomoki Ito Yoshinori Hashimoto Kotaro Shide Hiroshi Kawano Masaaki Sekine Takanori Toyama Hiromitsu Iizuka Seiichi Sato Masanori Takeuchi Junzo Ishizaki Kouichi Maeda Michikazu Nakai Kiyoshi Yamashita Yoko Kubuki Source Type: research