BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease

CONCLUSIONS: These findings suggest that reduced neurotrophic support, which is associated with Met66 carriage, may increase vulnerability to Aβ-related tau hyperphosphorylation, neuronal dysfunction, and cognitive decline even prior to the emergence of dementia. Additionally, these findings highlight the need for neuropsychological and clinicopathological models of AD to account for neurotrophic factors and the genes which moderate their expression.PMID:38454193 | DOI:10.1093/arclin/acae014

Source: Archives of Clinical Neuropsychology - March 7, 2024 Category: Psychiatry & Psychology Authors: Diny Thomson Emily Rosenich Paul Maruff Yen Ying Lim Alzheimer ’s Disease Neuroimaging Initiative Source Type: research