Revisiting roles of mast cells and neural cells in keloid: exploring their connection to disease activity

ConclusionsscRNA-seq analyses of AK, IK, and MS samples unveiled substantial microenvironmental heterogeneity. Such heterogeneity might be linked to disease activity. These findings suggest the potential contribution of MCs and NCs to keloid pathogenesis. Histopathological and molecular features observed in AK and IK samples provide valuable insights into the mechanisms underlying pain and pruritus in keloid lesions.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research