Early onset of abnormal glucose tolerance in patients with cystic fibrosis: A systematic review and meta-analysis

Cystic fibrosis (CF, OMIM: 219,700) is the most prevalent autosomal recessive disease, affecting 1 in 3500 neonates [1]. Over 2000 CF-causing mutations have been discovered in the CF transmembrane conductance regulator (CFTR) gene, reducing chloride, sodium, and bicarbonate ion transport, which leads to excessive mucus production, disrupting the function of various organs (e.g. airways, gastrointestinal system), including the pancreas [2 –4].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Review Source Type: research