Supercharging cancer-fighting T  cells with lithium carbonate

Cell Metab. 2024 Mar 5;36(3):463-465. doi: 10.1016/j.cmet.2024.02.006.ABSTRACTLactate influences the behavior of various immune cell types. In a recent Nature Immunology study, Ma et al. revealed that lithium carbonate induces monocarboxylate transporter 1 translocation to mitochondria, enhancing cytoplasmic lactate transport into the mitochondria and increasing lactate mitochondrial metabolism, thereby promoting T cell effector function.PMID:38447529 | DOI:10.1016/j.cmet.2024.02.006

Source: Cell Metabolism - March 6, 2024 Category: Cytology Authors: Yue Xu Kaili Ma Lianjun Zhang Guideng Li Source Type: research