Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3 β pathway in depressed mice

CONCLUSION: This study establishes how ODEXs improve depressive-like behaviors and hippocampal neuroplasticity and might provide a promising therapeutic approach for depression.PMID:38439616 | PMC:PMC10912796 | DOI:10.1111/cns.14661

Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Honghan Zhang Xin-Hui Xie Shu-Xian Xu Chao Wang Siqi Sun Xinhua Song Ruiling Li Ningyuan Li Yuqi Feng Hao Duan Di Li Zhongchun Liu Source Type: research